I-GENE Public VRE
THE I-GENE CONCEPT
Although CRISPR/Cas9 and enzyme-based editors hold promise for genome surgery by erasing harmful mutations while rewriting them in helpful ones, they still face critical barriers related to delivery and safety.
Our methodology relies on the development of a Cas9 nanoformulation, which triggers a light-switchable DNA double-strand break or cleavage.
Why has the I-GENE tech superior delivery properties?
The I-GENE vector has the ability of spontaneous nuclear localization of the editing machinery.
Why does I-GENE tech offer a superior safety profile?
Thanks to an approach of synthetic biology, I-GENE tech implements a concept of multi-input AND gates, where the output (gene editing) is true only if multiple inputs are simultaneously true, making off-target events unlike to occur.
